Study to synthesize and characterize host-guest encapsulation of antidiabetic drug (TgC) and hydroxy propyl-β-cyclodextrin augmenting the antidiabetic applicability in biological system
| Autor: | Tulika Ghosh, Raja Ghosh, Koyeli Das, Niloy Roy, Debadrita Roy, Mahendra Nath Roy |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
chemistry.chemical_classification
Natural product Cyclodextrin 010405 organic chemistry Chemistry Hydrochloride Organic Chemistry technology industry and agriculture Biological activity 010402 general chemistry 01 natural sciences Combinatorial chemistry Fluorescence spectroscopy 0104 chemical sciences Analytical Chemistry Inorganic Chemistry chemistry.chemical_compound Trigonelline Proton NMR Fourier transform infrared spectroscopy Spectroscopy |
| Zdroj: | Journal of Molecular Structure. 1179:642-650 |
| ISSN: | 0022-2860 |
| DOI: | 10.1016/j.molstruc.2018.11.049 |
| Popis: | An inclusion complex of a biologically active alkaloid Trigonelline hydrochloride (TgC) and hydroxypropyl-β-cyclodextrin (HP-β-CD) was prepared and characterized by several physicochemical and spectroscopic methods. The Trigonelline/HP-β-CD inclusion complex was confirmed by UV–vis Job's plot, fluorescence, conductance and SEM. Here, the inclusion mode is described with regard to structural aspect using 1H NMR, FTIR spectroscopy. Trigonelline hydrochloride (TgC) being an anti diabetic natural product, its inclusion complex was precisely checked for its sustained release by fluorescence spectroscopy. |
| Databáze: | OpenAIRE |
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