Changes in Sphingomyelinase Activity, Tumor Necrosis Factor α Level, and Lipid Peroxidation Intensity in the Course of Development of Cholestatic Liver Injury
| Autor: | A. V. Alessenko, G. G. Akhaladze, A. N. Tsupko, N. I. Shono, V. V. Yasnetsov, Shingarova Ln, M. A. Shupik, L. B. Dudnik, L. V. Platonova, Emilia Galperin |
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| Rok vydání: | 2005 |
| Předmět: |
Liver injury
medicine.medical_specialty Sphingomyelinase activity Biology medicine.disease General Biochemistry Genetics and Molecular Biology Lipid peroxidation chemistry.chemical_compound Endocrinology chemistry Cholestasis Apoptosis Internal medicine Immunology medicine Linear correlation General Agricultural and Biological Sciences Sphingomyelin Tumor necrosis factor α |
| Zdroj: | Biology Bulletin. 32:537-544 |
| ISSN: | 1608-3059 1062-3590 |
| DOI: | 10.1007/s10525-005-0140-0 |
| Popis: | Changes in sphingomyelinase activity, tumor necrosis factor α expression, and level of lipid peroxidation products in the course of development of cholestatic liver injury have been studied. The same type phase shifts in the analyzed parameters were observed, which included a marked decrease at the early stages of cholestasis (days 3–6) and a pronounced increase at the later stages (days 12–16), i.e., under the conditions of developed pathology. There was a significant positive linear correlation between tumor necrosis factor α expression, sphingomyelinase activity, and lipid peroxidation intensity in cholestatic injury. We propose that detected changes may reflect the balance between the effects of the two major bile components—bilirubin, which is accumulated in the liver at the early stages of cholestasis, and bile acids, whose influence dominates at the later stages of pathologic process. Our results indicate that tumor necrosis factor α overexpression, sphingomyelin cycle activation, and lipid peroxidation intensification may cause apoptosis of hepatocytes at the late stages of cholestasis. |
| Databáze: | OpenAIRE |
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