Associations of functional candidate genes derived from gene-expression profiles of prenatal porcine muscle tissue with meat quality and muscle deposition
| Autor: | Karl Schellander, I. Böll, J. W. M. Merks, M. Cagnazzo, Silvia Braglia, Mária Murániová, Kin-Chow Chang, H. Henne, D. Prins, M.F.W. te Pas, A.A.C. de Wit, Barbara Harlizius, S. Ponsuksili, Eduard Murani, Klaus Wimmers, Luca Fontanesi, N da Costa, Roberta Davoli |
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| Rok vydání: | 2007 |
| Předmět: | |
| Zdroj: | Animal Genetics. 38:474-484 |
| ISSN: | 1365-2052 0268-9146 |
| DOI: | 10.1111/j.1365-2052.2007.01639.x |
| Popis: | Ten genes (ANK1, bR10D1, CA3, EPOR, HMGA2, MYPN, NME1, PDGFRA, ERC1, TTN), whose candidacy for meat-quality and carcass traits arises from their differential expression in prenatal muscle development, were examined for association in 1700 performance-tested fattening pigs of commercial purebred and crossbred herds of Duroc, Pietrain, Pietrain × (Landrace × Large White), Duroc × (Landrace × Large White) as well as in an experimental F2 population based on a reciprocal cross of Duroc and Pietrain. Comparative sequencing revealed polymorphic sites segregating across commercial breeds. Genetic mapping results corresponded to pre-existing assignments to porcine chromosomes or current human?porcine comparative maps. Nine of these genes showed association with meat-quality and carcass traits at a nominal P-value of ? 0.05; PDGFRA revealed no association reaching the P ? 0.05 threshold. In particular, HMGA2, CA3, EPOR, NME1 and TTN were associated with meat colour, pH and conductivity of loin 24 h postmortem; CA3 and MYPN exhibited association with ham weight and lean content (FOM) respectively at P-values of |
| Databáze: | OpenAIRE |
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