Menstrual and reproductive factors and lung cancer risk: A pooled analysis from the international lung cancer consortium

Autor:	A. Papadopoulos, Angela Cecilia Pesatori, Nancy Diao, Isabelle Stücker, David C. Christiani, Rayjean J. Hung, John R. McLaughlin, Anita Koushik, Kai Uwe Saum, Irene Orlow, Michele L. Cote, Monica Neri, Curtis C. Harris, Eric J. Duell, Ann G. Schwartz, Hermann Brenner, Angeline S. Andrew, Jack Siemiatycki, Susan Olivo-Marston, Soumaya Ben Khedher, Bernard J. Park, Maria Teresa Landi
Rok vydání:	2017
Předmět:	0301 basic medicine Gynecology Cancer Research medicine.medical_specialty Obstetrics business.industry Breastfeeding Case-control study Logistic regression medicine.disease Menstruation Menopause 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Oncology 030220 oncology & carcinogenesis medicine Menarche Risk factor business Lung cancer
Zdroj:	International Journal of Cancer. 141:309-323
ISSN:	0020-7136
DOI:	10.1002/ijc.30750
Popis:	Many clinical features of lung cancer are different in women and men. Sex steroid hormones exert effects in nonreproductive organs, such as the lungs. The association between menstrual and childbearing factors and the risk of lung cancer among women is still debated. We performed a pooled analysis of eight studies contributing to the International Lung Cancer Consortium (4,386 cases and 4,177 controls). Pooled associations between menstrual or reproductive factors and lung cancer were estimated using multivariable unconditional logistic regression. Subgroup analyses were done for menopause status, smoking habits and histology. We found no strong support for an association of age at menarche and at menopause with lung cancer, but peri/postmenopausal women were at higher risk compared to premenopausal (OR 1.47, 95% CI 1.11-1.93). Premenopausal women showed increased risks associated with parity (OR 1.74, 95% CI 1.03-2.93) and number of children (OR 2.88, 95% CI 1.21-6.93 for more than 3 children; p for trend 0.01) and decreased with breastfeeding (OR 0.54, 95% CI 0.30-0.98). In contrast, peri/postmenopausal subjects had ORs around unity for the same exposures. No major effect modification was exerted by smoking status or cancer histology. Menstrual and reproductive factors may play a role in the genesis of lung cancer, yet the mechanisms are unclear, and smoking remains the most important modifiable risk factor. More investigations in large well-designed studies are needed to confirm these findings and to clarify the underlying mechanisms of gender differences in lung cancer risk.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e5c1966691649494c29a0b9dceb6b6c7 https://doi.org/10.1002/ijc.30750 Zobrazit plný text záznamu Plný text