Rearrangement of thiazolo[3,2-a]pyrimidines into triazolo[4,3-a]pyrimidines induced by C=N bond reduction

Autor:	Eugenia A. Lashmanova, Victor B. Rybakov, A. K. Shiryaev, Artem S. Agarkov
Rok vydání:	2019
Předmět:	chemistry.chemical_compound 010405 organic chemistry Chemistry Organic Chemistry Hydroxymethyl 010402 general chemistry 01 natural sciences Single crystal Medicinal chemistry Hydrazine derivatives 0104 chemical sciences
Zdroj:	Chemistry of Heterocyclic Compounds. 55:1217-1221
ISSN:	1573-8353 0009-3122
DOI:	10.1007/s10593-019-02604-4
Popis:	Triazolo[4,3-a]pyrimidines were prepared by the reduction of 5,6,7-trisubstituted 2-(arylhydrazinylidene)-5H-[1,3]thiazolo[3,2-a]- pyrimidin-3(2H)-ones with NaBH4 in the presence of V2O5 at room temperature. The structure of ethyl 3-(hydroxymethyl)- 5-(4-methoxyphenyl)-7-methyl-1-phenyl-1,5-dihydro[1,2,4]triazolo[4,3-a]pyrimidine-6-carboxylate was proven by the single crystal X-ray diffraction data. The mechanism of the reaction including transition cage structure is discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e5bbdad80f2fe8ccebff8b3796b4c256 https://doi.org/10.1007/s10593-019-02604-4 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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