ChemInform Abstract: Palladium-Catalyzed Enantioselective Allylic Alkylation of Trifluoromethyl Group Substituted Racemic and Acyclic Unsymmetrical 1,3-Disubstituted Allylic Esters with Malonate Anions

Autor:	Kazunori Ikeda, Takashi Futamura, Motoi Kawatsura, Maki Minakawa, Taisyun Hanakawa
Rok vydání:	2016
Předmět:	chemistry.chemical_classification Allylic rearrangement Trifluoromethyl Base (chemistry) Enantioselective synthesis chemistry.chemical_element General Medicine Medicinal chemistry Catalysis chemistry.chemical_compound Tsuji–Trost reaction Malonate chemistry Palladium
Zdroj:	ChemInform. 47
ISSN:	0931-7597
Popis:	We examined the palladium-catalyzed allylic alkylation of trifluoromethyl group-substituted racemic and acyclic unsymmetrical 1,3-disubstituted allylic benzoate with a malonate anion, and succeeded in obtaining an enantiomerically enriched product in high yields with high ee values through the dynamic kinetic asymmetric transformation (DYKAT). The best result was attained by the [Pd(C3H5)(cod)]BF4/(S)-tol-BINAP in the presence of BSA or DMAP as a base.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e5ba57290abf8a92fc36260b5beff07e https://doi.org/10.1002/chin.201631024 Zobrazit plný text záznamu Plný text