Ist NGS der bessere Spürhund bei Akuter Lymphatischer Leukämie?

Autor:	Christiane Pott, Michael Kneba, Henrik Knecht, Heiko Trautmann, Dietrich Herrmann, Monika Brüggemann, Marc Füllgrabe, Matthias Ritgen
Rok vydání:	2015
Předmět:	Oncology medicine.medical_specialty Lymphoblastic Leukemia T-cell receptor Pharmacology toxicology Gold standard (test) Biology Minimal residual disease body regions hemic and lymphatic diseases Internal medicine Immunology medicine Molecular Biology Biotechnology
Zdroj:	BIOspektrum. 21:58-61
ISSN:	1868-6249 0947-0867
Popis:	Minimal residual disease (MRD) has become an important tool for risk assessment and treatment stratification in hematological malignancies such as acute lymphoblastic leukemia (ALL). Currently, MRD is under discussion as new endpoint in clinical trials. Allele-specific real-time quantitative RQ-PCR is the gold standard for molecular quantification of clonal immunoglobuline and T-cell receptor (IG/TCR) gene rearrangements but next generation sequencing may overcome current limitations of IG/TCR based MRD assessment.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e5b58f2ae194d9d1e700fa9bf45de5d0 https://doi.org/10.1007/s12268-015-0540-8 Zobrazit plný text záznamu Full text from SpringerLink