Double Application of Translocator Protein Ligands and RAW Cells Inflammatory Milieu
| Autor: | Maria A. Staykova, Filomena Mattner, David Linares, Andrew Katsifis |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Aryl hydrocarbon receptor nuclear translocator Ligand Immunology Multiple applications Biology Neuroprotection 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Biochemistry Translocator protein biology.protein Immunology and Allergy Macrophage 030217 neurology & neurosurgery |
| Zdroj: | American Journal of Immunology. 12:56-60 |
| ISSN: | 1553-619X |
| Popis: | Ligands targeting the translocator protein exhibit a variety of anti-inflammatory and neuroprotective properties. A double application of eight translocator protein ligands to activated murine macrophage-like cells changed to a different extent the levels of secreted reactive nitrogen intermediates, pro- and anti-inflammatory cytokines. To our knowledge this is the first report suggesting that multiple applications of different translocator protein ligands may have selective effects on the macrophage inflammatory milieu that do not appear to be related to just the ligand affinity. |
| Databáze: | OpenAIRE |
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