Phytoprostane and phenolic compounds from Chromolaena palmaris
| Autor: | Anderson V. G. Ramos, Debora Cristina Baldoqui, Mariana Regina Passos Souza, Márcia Regina Pereira Cabral, Ana Lúcia Tasca Gois Ruiz, Maria Helena Sarragiotto, Mary Ann Foglio, Regiane Bertin de Lima Scodro, Eloísa G Sampiron, Marta Regina Barrotto do Carmo, Josiane A Monteiro de Oliveira |
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| Rok vydání: | 2021 |
| Předmět: |
Traditional medicine
biology 010405 organic chemistry Organic Chemistry Plant Science Asteraceae biology.organism_classification Antimicrobial 01 natural sciences Biochemistry 0104 chemical sciences Analytical Chemistry Mycobacterium tuberculosis Chromolaena 010404 medicinal & biomolecular chemistry chemistry.chemical_compound chemistry Phytochemical composition Cytotoxicity Human cancer Dichloromethane |
| Zdroj: | Natural Product Research. 36:5376-5379 |
| ISSN: | 1478-6427 1478-6419 |
| Popis: | The chemical investigation of Chromolaena palmaris (Sch.Bip. ex Baker) R.M. King & H. Rob. expands the phytochemical composition knowledge of Chromolaena genus, since this is the first chemical investigation of this species. Twenty-five compounds were identified, including a phytoprostane, 17 flavonoids, 6 phenolic acids, and a caffeoyl-glucoside derivative obtained by classical chromatography and UHPLC-HRMS/MS analysis. Moreover, anti-Mycobacterium tuberculosis and antiproliferative activities of C. palmaris were evaluated. Dichloromethane fraction showed cytotoxicity towards human cancer cell lines, presenting TGI values on glioma (U251) of 27.8 μg mL-1. Furthermore, compounds 1 and 2 exhibited antimicrobial activity against Mycobacterium tuberculosis with MIC of 62.5 and 15.6 μg mL-1, respectively. |
| Databáze: | OpenAIRE |
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