Effects on gene expression
| Autor: | S. Kitayama, S. P. Williams, J. McCoy, Hiroshi Yamashita, Tetsuya Takahashi, T. Dohi, A. V. Terry, Burt M. Sharp, R. L. Martone, S. L. Orr, Jayashree Rao, J. Valentine, Y-X. Zhang, Bryan Bienvenu, T. Kawarai, Hideo Kiba, M. S. F. Clarke, A. Jayaraman, J. L. Jeffries-Griffor, L. Ahtee, Shigenobu Nakamura, S. Sudoh, O. Salminen, Hideshi Kawakami, Shannon G. Matta |
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| Rok vydání: | 1994 |
| Předmět: |
endocrine system
0303 health sciences medicine.medical_specialty Lateral hypothalamus Biology Supraoptic nucleus 3. Good health Nicotine 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Endocrinology nervous system Hypothalamus Parvocellular cell Internal medicine Gene expression Mecamylamine medicine Nucleus hormones hormone substitutes and hormone antagonists 030217 neurology & neurosurgery 030304 developmental biology medicine.drug |
| Zdroj: | Experientia Supplementum ISBN: 9783764350871 |
| Popis: | Subcutaneous injections of nicotine (0.4 to 1.0 mg/kg) in adult male rats resulted in the induction of c-fos gene most prominently and selectively in the parvocellular, but not the magnocellular subdivision of the hypothalamic paraventricular nucleus. A significant number of neurons in the superficial regions of the supraoptic nucleus also contained Fos reactivity, but only with larger doses (1.0 mg/kg) of nicotine. Fos immunoreactive neurons were also prominent in the supramammillary regions. The lateral preoptic area, the anterior and posterior aspects of the lateral hypothalamus contained significant number of Fos immunoreactive neurons. The medial preoptic area, the suprachiasmatic and the periventricular nuclei of the hypothalamus were relatively free of Fos reactive neurons. Injections of mecamylamine completely abolished nicotine induced Fos immunoreactivity in all of these cases. These results suggest that acute injections of nicotine induce intense Fos expression in two major areas of the rat hypothalamus, namely 1 the CRF neurons of the parvocellular paraventricular nucleus, an area of the hypothalamus recognized to mediate stress response and 2. the lateral preoptic areas and the lateral hypothalamus, regions of the hypothalamus strongly implicated in intracranial self-stimulation behavior. Supported by The Smokeless Tobacco Research Council, N.Y., and the Department of Defense, U.S.A. |
| Databáze: | OpenAIRE |
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