P286 Visual and brainstem auditory evoked potentials abnormalities in the patients with systemic lupus erythematosus
| Autor: | Marta Waliszewska-Prosół, Magdalena Szmyrka, Piotr Wiland, Anna Pokryszko-Dragan, Elżbieta Kusińska, Ryszard Podemski, Edyta Dziadkowiak |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Nervous system
medicine.medical_specialty Systemic disease Lupus erythematosus genetic structures business.industry Central nervous system Disease Brain damage medicine.disease Sensory Systems medicine.anatomical_structure Neurology Physiology (medical) Internal medicine medicine Cardiology Neurology (clinical) Brainstem medicine.symptom business Subclinical infection |
| Zdroj: | Clinical Neurophysiology. 128:e269 |
| ISSN: | 1388-2457 |
| DOI: | 10.1016/j.clinph.2017.07.294 |
| Popis: | Objectives Lupus erythematosus (SLE) is a systemic disease with possible nervous system involvement, regarded as unfavorable prognostic factor. Evoked potentials (EP) are electrophysiological markers of disturbed central nervous system (CNS) function, even in subclinical stage of CNS disorders. The purpose of the study was to evaluate parameters of EP in the patients with SLE with or without neuropsychiatric manifestation (NPSLE). Methods The study comprised 53 patients with SLE (49 women, 4 men, aged 21–62, mean 38.3) and 40 healthy, age- and gender- matched controls. 33 patients were classified as having NPSLE. Visual evoked potentials (VEP) and brainstem auditory evoked potentials (BAEP) were performed in all the subjects. Latencies and amplitudes of VEP and BAEP components were compared between SLE patients and controls and between NPSLE and non-NPSLE patients. Results Mean latency of P100 component of VEP for the right eye was significantly longer (104.3 ms vs 102.06 ms; p = 0.05) and mean amplitude of the I component of BAEP for the right ear was significantly lowered (0.25 μ V vs 0.30 μ V; p = 0.04) in the SLE patients in comparison with the controls. No differences were found between NPSLE and non-NPSLE patients. Discussion Asymmetric abnormalities of EP correspond with multifocal brain damage in the course of SLE, although they are not specific for the background of the disease. Conclusions and significance Parameters of VEP and BAEP show asymmetric abnormalities in SLE patients, regardless of the clinical symptoms of CNS involvement. EP may be considered as electrophysiological markers of early CNS dysfunction in the course of SLE. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect