Ozone Therapy Ameliorates Nervous System Disorders and Oxidative Stress in Patients During Ethanol Withdrawal—A Pilot Study

Autor:	Olga Sonia León Fernández, Ángela Fraga Pérez, Jaqueline Dranguet Vaillant, María Teresa Díaz-Soto, A. Mallok, Silvia Menéndez Cepero, Renate Viebahn-Hänsler
Rok vydání:	2012
Předmět:	Nervous system Environmental Engineering Central nervous system Acetaldehyde Regulator Brain damage Pharmacology Ozone therapy medicine.disease_cause Withdrawal Scale Toxicology chemistry.chemical_compound medicine.anatomical_structure chemistry medicine Environmental Chemistry medicine.symptom Oxidative stress
Zdroj:	Ozone: Science & Engineering. 34:432-437
ISSN:	1547-6545 0191-9512
Popis:	Chronic oxidative stress and acetaldehyde accumulation are associated with brain damage during Ethanol Withdrawal (EW). Ozone therapy is a regulator of cellular redox balance and it controls important functions of nervous system during EW at experimental level. The aim of this work was to develop a pilot study in order to evaluate the ozone´s effects on EW signs and oxidative stress in 10 patients “Before” and “After” ozone treatments. Ozone improved 70% of the signs from Clinical Institute Withdrawal Scale (CIWA-Ar), mainly those associated to Central Nervous System (CNS). Ozone´s efficacy was observed in patients that required pharmacological treatment. Reduction of CIWA-Ar scores and the oxidative stress (p < 0.05) was demonstrated. In summary, ozone improved CNS functions and reduced oxidative stress in patients during EW. These results were according to experimental findings and suggest ozone´s regulator effects on important neurotransmitters of the CNS.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e5ac625aa60a823b0e86d91a962af60b https://doi.org/10.1080/01919512.2012.717858 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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