Dysgerminoma, gonadoblastoma, and testicular germ cell neoplasia in phenotypically female and male siblings with 46 XY genotype

Autor:	Felicity A. Frost, William O. C. M. Cookson, Andrew C. Kingsbury
Rok vydání:	1987
Předmět:	endocrine system Cancer Research medicine.medical_specialty XY Genotype Cancer Gonadoblastoma Physiology Biology Testicle medicine.disease Testicular germ cell XY gonadal dysgenesis Endocrinology medicine.anatomical_structure Oncology Internal medicine medicine Dysgerminoma Germ cell tumors
Zdroj:	Cancer. 59:288-291
ISSN:	1097-0142 0008-543X
DOI:	10.1002/1097-0142(19870115)59:2<288::aid-cncr2820590219>3.0.co;2-n
Popis:	46 XY gonadal dysgenesis is a syndrome characterized by a female phenotype with streak gonads and complicated by the frequent occurrence of germ cell tumors. The syndrome and the risk of malignant disease occur in female siblings sharing the XY genotype, and screening of female siblings and prophylactic gonadectomy in those affected is generally recommended. A family of four siblings is described in which two phenotypically female XY children and one male each have developed germ cell tumors, demonstrating that brothers of affected sisters may also be at risk. Cancer 59:288–291, 1987.
Databáze:	OpenAIRE
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