Long-Term Effects of Fetal Exposure to Low Doses of the Xenoestrogen Bisphenol-A in the Female Mouse Genital Tract1
| Autor: | Beverly S. Rubin, Caroline M. Markey, Carlos Sonnenschein, Perinaaz R. Wadia, Ana M. Soto |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Estrous cycle
endocrine system Fetus medicine.medical_specialty Lamina propria urogenital system medicine.drug_class Offspring Physiology Cell Biology General Medicine Biology chemistry.chemical_compound Endocrinology medicine.anatomical_structure Xenoestrogen Reproductive Medicine chemistry Estrogen In utero Internal medicine medicine Vagina hormones hormone substitutes and hormone antagonists |
| Zdroj: | Biology of Reproduction. 72:1344-1351 |
| ISSN: | 1529-7268 0006-3363 |
| DOI: | 10.1095/biolreprod.104.036301 |
| Popis: | Developmental exposure to estrogenic chemicals induces morphological, functional, and behavioral anomalies associated with reproduction. Humans are routinely exposed to bisphenol-A (BPA), an estrogenic compound that leaches from dental materials and plastic food and beverage containers. The aim of the present study was to determine the effects of in utero exposure to low, environmentally relevant doses of BPA on the development of female reproductive tissues in CD-1 mice. In previous publications, we have shown that this treatment alters the morphology of the mammary gland and affects estrous cyclicity. Here we report that in utero exposure to 25 and 250 ng BPA/ kg of body weight per day via osmotic pumps implanted into pregnant dams at Gestational Day 9 induces alterations in the genital tract of female offspring that are revealed during adulthood. They include decreased wet weight of the vagina, decreased volume of the endometrial lamina propria, increased incorporation of bromodeoxyuridine int... |
| Databáze: | OpenAIRE |
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