| Autor: |
C. N. Bennett, D. F. Horrobin |
| Rok vydání: |
1999 |
| Předmět: |
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| Zdroj: |
Search for the Causes of Schizophrenia ISBN: 9783642470783 |
| DOI: |
10.1007/978-3-642-47076-9_19 |
| Popis: |
The membrane phospholipid hypothesis suggests that the primary abnormality in schizophrenia is in phospholipid biochemistry. This particularly applies to mechanisms regulating highly unsaturated fatty acid metabolism at the Sn2 position of phospholipid molecules. As a consequence there are abnormalities of neuronal membrane structure and cell signalling. These lead secondarily to disturbances in neurotransmitter and ion channel-related mechanisms. Two separate abnormalities of phospholipid metabolism are proposed. They are present throughout the body and can be detected in red blood cells and also in the skin during stimulation of arachidonic acid metabolism by niacin. One of them may also be identified by abnormal P50 gating. Novel therapies based on this concept have yielded good results in clinical trials with none of the usual side effects of either typical or atypical neuroleptics. The phospholipid concept offers a new approach to the problems of understanding and treating schizophrenia. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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