Abstract P618: Visceral and Subcutaneous Adipokine Expression and Serum Adipokine Levels Are Differentially Associated With Metabolic Risk
| Autor: | Bige Ozkan, Amelia S Wallace, Carine Hamo, Risa Wolf, Justin B Echouffo Tcheugui, Alexander Arking, Gary Gerstenblith, Xin Chu, G. Craig Wood, Peter Benotti, G William Wong, Josef Coresh, Chiadi E Ndumele |
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| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Circulation. 147 |
| ISSN: | 1524-4539 0009-7322 |
| DOI: | 10.1161/circ.147.suppl_1.p618 |
| Popis: | Background: Adipokines mediate many metabolic effects of adipose tissue. While regional body composition is associated with metabolic risk, it is unclear if metabolic risk associations differ for adipokine expression in visceral and subcutaneous tissue and adipokine concentrations in the circulation. Methods: We obtained visceral and subcutaneous fat samples, and pre-surgical serum samples from Geisinger Obesity Registry patients undergoing bariatric surgery. We used real-time PCR to quantify mRNA expression of adipokines (adiponectin, leptin, leptin/adiponectin ratio) in fat samples, and targeted assays (ELISA) to measure serum adipokines. Using multivariable linear regression, we evaluated the individual and combined associations of visceral, subcutaneous and serum adipokines (per-1-SD and tertiles) with a metabolic syndrome (MetS) severity Z-score. Results: 181 participants (mean age 45 years, mean BMI 47 kg/m 2 , 85% female) with available fat and serum samples were included. Visceral, subcutaneous and serum adipokines were all weakly correlated (all ρ Conclusion: Visceral, but not subcutaneous, adipokine expression provides complementary information to serum adipokines on metabolic risk. This indicates significant differences in the physiologic impact of regional adipose tissue and highlights adipokines as a potential target for modifying cardiometabolic risk. |
| Databáze: | OpenAIRE |
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