Synthesis of 4-(2-thiazolyloxy)phenylalkanoic acids as an antiinflammatory agent

Autor:	Byeng Wha Son, Sang Hoon Shin, Hong Dae Choi
Rok vydání:	1996
Předmět:	Isopropoxybenzene Chemistry Organic Chemistry Drug Discovery Pharmacology toxicology Molecular Medicine Organic chemistry Alkylation Friedel–Crafts reaction Isopropyl Flue-gas desulfurization
Zdroj:	Archives of Pharmacal Research. 19:148-152
ISSN:	1976-3786 0253-6269
Popis:	The efficient synthesis of 4-(2-thiazolyloxy)phenylalkanoic acids (10a-c), which are a potent antiinflammatory agent, was achieved in 5∼6 steps starting from isopropoxybenzene and methyl α-chloro-α-(methylthio)acetate (1). The key intermediate (4) was prepared by Friedel-Crafts reaction of isopropoxybenzene with (1) followed by desulfurization and the removal of isopropyl protector. Methyl 4-hydroxyphenylalkanoates (6,8) were similarly obtained from alkylation of (3) and deprotection.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e580695e1f3cc4c84b78c58ae5fa3f11 https://doi.org/10.1007/bf02976851 Zobrazit plný text záznamu Full text from SpringerLink