| Autor: |
Claudio Laurido, Bernardo Morales, Carlos Valdes, Luisauris Jaimes, José Luis Martínez, Raúl Vinet |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas. 19:420-427 |
| ISSN: |
0717-7917 |
| DOI: |
10.37360/blacpma.20.19.4.29 |
| Popis: |
The essential oil of Laurus nobilis L. was used to test their antinociceptive efficacy. It was applied intraperitoneally (i.p.) to rats subjected to a nociception test (C reflex and spinal wind-up). The results showed that the essential oil applied at higher doses (0.06 mg/Kg) causes a complete abolition of the spinal wind-up, while the C reflex was unchanged, indicating a clear antinociceptive effect. At lower concentrations (0.012 mg/Kg), there was a lowering in the wind-up by 85% within ten minutes of the essential i.p. oil application. Interestingly, there was an effect of naloxone (0.08 mg/Kg i.p.) When applied, a change occurs that almost entirely reversed the antinociception caused by the essential oil from Laurus nobilis. We conclude that there is a significant antinociceptive effect of the essential oil of Laurus nobilis subjected to electric nociception. In addition, it was observed that naloxone reversed the antinociceptive effect (windup) produced by Laurus nobilis. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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