Repetitive Suicidal Behaviors in a Case With a New Mutation of Wolfram Syndrome: A Jump From the Gene to the Behavior

Autor:	Mostafa Almasi-Dooghaee, Omid Aryani, Fatemeh Sadat Mirfazeli, Amin Jahanbakhshi, Fatemeh Mohebi
Rok vydání:	2022
Předmět:	Genetics Cellular and Molecular Neuroscience Wolfram syndrome business.industry New mutation medicine Jump Neurology (clinical) medicine.disease business Gene
Zdroj:	Basic and Clinical Neuroscience Journal. 13:893-900
ISSN:	2008-126X 2228-7442
Popis:	Wolfram syndrome (WS) is a rare autosomal recessive neurodegenerative disease with variable symptoms, including neuropsychiatric manifestations. A 26-year-old man was reported with classic symptoms of WS and repetitive psychiatric hospitalizations and at least 16 suicidal attempts. The genetic study demonstrated a novel homozygous stop-codon mutation on the WFS1 gene. This special type of mutation may be related to repetitive suicidal behaviors in this case of WS. Psychological support should be a routine practice in patients with WS.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e56afd723fa17b7af04fa871ef9ecedd https://doi.org/10.32598/bcn.2021.910.3 Zobrazit plný text záznamu Plný text ve formátu PDF