The Effects of Nicotine on Fracture Healing in Rats

Autor:	Nural Erdogan, Ethem Faruk Mumcu, Huseyin Yorgancigil, Remzi A. Ozerdemoglu, Feza Korkusuz
Rok vydání:	1998
Předmět:	business.industry medicine.medical_treatment Ulna Blood flow Bone healing Nicotine medicine.anatomical_structure Cigarette smoking Forearm Anesthesia medicine Orthopedics and Sports Medicine medicine.symptom business Saline Vasoconstriction medicine.drug
Zdroj:	Journal of Musculoskeletal Research. :289-296
ISSN:	1793-6497 0218-9577
DOI:	10.1142/s0218957798000299
Popis:	Cigarette smoking is regarded as a risk factor for developing complications in fracture healing. To determine whether nicotine would retard fracture healing in the rat, 25 rats were divided into two groups and given nicotine or saline subcutaneously at a dose of 2 mg/kg a day, for four weeks. Then their right forelimbs were broken. The rats were killed and histopathologic sections of the radius and ulna were examined and graded at the 7th and 21st days after fractures. Nicotine or saline treatment continued throughout the experiment. Median fracture healing score was found to be 0 (min. 0 - max. 1) in nicotine-treated rats, and 1 (min. 0 - max. 2) in controls, at the 7th day. At the 21st day, the median scores were 2 (min. 1 - max. 3), and 3 (min. 2 - max. 3) in experimental and control groups, respectively. Scores were significantly decreased in nicotine-treated rats both at the 7th and 21st days (p = 0.0465 and p = 0.0175, respectively). We suppose that nicotine impaired fracture healing in the rat forearm model possibly by diminishing nutritional blood flow via vasoconstriction and by its direct effect on osteogenesis.
Databáze:	OpenAIRE
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