| Autor: |
Eline Vonck, Veerle Baekelandt, Anna Barber Janer |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
International Review of Movement Disorders ISBN: 9780323899437 |
| DOI: |
10.1016/bs.irmvd.2021.09.001 |
| Popis: |
Animal models are essential to study the pathophysiology of Parkinson's disease and to develop disease-modifying therapies. The identification of α-synuclein as a disease-associated gene and the discovery of this protein as one of the major constituents of Lewy bodies, have prompted the generation of animal models based on α-synuclein transgenesis or viral vector-mediated α-synuclein overexpression. Later, new insights on the “prion-like” properties of α-synuclein led to a new generation of models for Parkinson's disease. These transmission models are developed by intracerebral inoculation of α-synuclein fibrils. Technical advancements and new insights into α-synuclein pathology have led to a wide array of available rodent models that have greatly contributed to our understanding of different aspects of Parkinson's disease. Each of these models has their own characteristics with certain advantages and limitations. The best choice of the animal model will be dependent on the specific question or scientific hypothesis to be tested. In this chapter, we give a comprehensive overview of the different α-synuclein-based rodent models that have been developed. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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