A new anti-diabetic sesquiterpenoid from Acorus calamus

Autor:	Jian Xia Mo, Chang Xin Zhou, Li She Gan, Di Qiao, You You Yan, Hao Shu Wu
Rok vydání:	2012
Předmět:	Quantum chemical biology Chemistry Stereochemistry Hepg2 cells Acorus calamus Absolute configuration General Chemistry Time-dependent density functional theory biology.organism_classification Two-dimensional nuclear magnetic resonance spectroscopy Rhizome
Zdroj:	Chinese Chemical Letters. 23:1165-1168
ISSN:	1001-8417
DOI:	10.1016/j.cclet.2012.08.004
Popis:	A new sesquiterpenoid, 1 β ,5 α -guaiane-4 β ,10 α -diol-6-one ( 1 ), was isolated from 70% EtOH extract of the rhizomes of Acorus calamus . The structure was determined on spectroscopic methods, especially 2D NMR techniques. The absolute configuration of 1 was confirmed by TDDFT quantum chemical calculation of its ECD spectrum. Compound 1 showed promising anti-diabetic activity on a insulin-mediated glucose consumption model of HepG2 cells.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e5602dd925530ba49fbb909a3f1ed014 https://doi.org/10.1016/j.cclet.2012.08.004 Zobrazit plný text záznamu Full Text from ScienceDirect