A Synthesis of imidazo- and pyrimido[1,2-g][1,6]naphthyridinones

Autor:	F. J. Villani, Richard Friary, J. H. Schwerdt, Vera Seidl
Rok vydání:	1990
Předmět:	chemistry.chemical_classification Potassium Organic Chemistry Condensation Imidazoline receptor chemistry.chemical_element Sodium methoxide Medicinal chemistry Chloride chemistry.chemical_compound chemistry medicine Lactam Organic chemistry Tricyclic medicine.drug
Zdroj:	Journal of Heterocyclic Chemistry. 27:189-193
ISSN:	1943-5193 0022-152X
DOI:	10.1002/jhet.5570270214
Popis:	Arylmethylimidazolines and (3-chlorophenyl)methyl-1,4,5,6-tetrahydropyrimidine amidated 2-chloro-3-pyridinecarbonyl chloride and potassium t-butoxide cyclized the products to linearly fused, tricyclic imidazo-and pyrimido[1,2-g][1,6]naphthyridinones. Condensation of ethyl 2-chloro-3-pyridinecarboxylate with 2-(phenylmethyl)imidazoline in the presence of sodium methoxide directly formed the isomeric, angularly fused 8,9-dihydro-6-phenylimidazo[1,2-a][1,8]naphthyridin--5(7H)-one.
Databáze:	OpenAIRE
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