CNS Depressant and Analgesic Activity of a Fraction Isolated from an Ethanol Extract ofCurcuma amadaRhizomes
| Autor: | Dattatraya G. Naik, A. M. Mujumdar, Hemalata M. Puntambekar, Chitra Dandge, Ashwini V. Misar |
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| Rok vydání: | 2004 |
| Předmět: |
Pharmacology
Ethanol biology Ethyl acetate Pharmaceutical Science General Medicine Pharmacognosy biology.organism_classification food.food Rhizome chemistry.chemical_compound food Column chromatography Complementary and alternative medicine chemistry Drug Discovery Molecular Medicine Zingiberaceae Curcuma Curcuma amada |
| Zdroj: | Pharmaceutical Biology. 42:542-546 |
| ISSN: | 1744-5116 1388-0209 |
| DOI: | 10.3109/13880200490893429 |
| Popis: | In our earlier studies, an ethanol extract of Curcuma amada Roxb. rhizome was reported for anti-inflammatory activity. This ethanol extract was successively partitioned with hexane and ethyl acetate. Each fractionated extract was screened for anti-inflammatory activity, and the most active fraction was purified by column chromatography. This resulted in isolation of the active fraction F, which was characterized by spectral methods. Fraction F was studied for its effect on general behavioral studies in albino mice. Based on these observations, pharmacological investigations were carried out by adopting the following methods in albino mice: effect on exploratory activity, barbiturate sleeping time, acetic acid–induced writhing, and tail-flick test. This fraction showed reduction in exploratory activity and potentiation of barbiturate sleeping time, indicating CNS depressant activity. Further, it also showed reduction in acetic acid–induced writhings, tail-flick response, and carrageenan-induced inflammatio... |
| Databáze: | OpenAIRE |
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