Borylation of Unactivated C(sp3)–H Bonds with Bromide as a Traceless Directing Group
| Autor: | Zhi-Tao He, Wen-Bo Ye, Meng-Yao Li, Ge Zhang, Chen-Guo Feng, Guo-Qiang Lin |
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| Rok vydání: | 2021 |
| Předmět: |
inorganic chemicals
chemistry.chemical_classification 010405 organic chemistry Chemistry Site selectivity Organic Chemistry Substrate (chemistry) 010402 general chemistry 01 natural sciences Biochemistry Borylation Combinatorial chemistry 0104 chemical sciences Stereocenter chemistry.chemical_compound Bromide Group (periodic table) Functional group Physical and Theoretical Chemistry Alkyl |
| Zdroj: | Organic Letters. 23:2948-2953 |
| ISSN: | 1523-7052 1523-7060 |
| DOI: | 10.1021/acs.orglett.1c00617 |
| Popis: | A palladium-catalyzed alkyl C-H borylation with bromide as a traceless directing group is described, providing a convenient approach to access alkyl boronates bearing a β-all-carbon quaternary stereocenter. The protocol features a broad substrate scope, excellent site selectivity, and good functional group tolerance. |
| Databáze: | OpenAIRE |
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