Influence of UGT genetic polymorphism on the interindividual variability in mitiglinide pharmacokinetic in Chinese

Autor:	Zhan-qing Wang, Lin Xu, Yong-ge Yang, Gang-tao Zhao, Jing-feng Xu, Chen-xia Yan, Qian Xu
Rok vydání:	2011
Předmět:	Mitiglinide Pharmacokinetics Chemistry Organic Chemistry Pharmacology toxicology Genotype medicine Cmax Genetic data PK Parameters General Pharmacology Toxicology and Pharmaceutics Pharmacology medicine.drug
Zdroj:	Medicinal Chemistry Research. 21:2595-2602
ISSN:	1554-8120 1054-2523
DOI:	10.1007/s00044-011-9784-0
Popis:	The aim of the study is to identify the effect of UDP-glucuronosyltransferase (UGT) genetic polymorphism on the interindividual variability in mitiglinide pharmacokinetics (PK) in Chinese. PK and genetic data were obtained from 42 healthy Chinese volunteers (Han ethnic group) treated with single-dose and multiple-dose oral mitiglinide using liquid chromatography/mass spectrometry and DNA sequencing technologies. And the result showed there were great interindividual variabilities in main PK parameters (AUC, Cmax and CL/F) for multiple oral mitiglinide. The enzyme activity of the carriers of UGT1A3 *2/*4 or UGT2B7-1 T/T was stronger than that of the carriers of other genotypes. These results demonstrate that UGT1A3 and UGT2B7-1 genetic polymorphism may have a significant impact on interindividual variability in the PK of mitiglinide in Chinese.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e53d04448d458285d46392d2b470d7c4 https://doi.org/10.1007/s00044-011-9784-0 Zobrazit plný text záznamu Full text from SpringerLink