Orthoamides and Iminium Salts, LXXV [1]. Contribution to the Formation of 2-Formyl-1,1,3,3-tetramethylguanidine and the Isomeric 1,1-Dimethyl-3-dimethylaminomethylene-urea

Autor:	Willi Kantlehner, Ivo C. Ivanov, Ioannis Tiritiris
Rok vydání:	2012
Předmět:	Formamide 1 1 3 3-Tetramethylguanidine chemistry.chemical_compound Chemistry Stereochemistry Reagent Iminium General Chemistry Crystal structure Nuclear magnetic resonance spectroscopy Guanidine Medicinal chemistry Adduct
Zdroj:	Zeitschrift für Naturforschung B. 67:331-336
ISSN:	1865-7117 0932-0776
DOI:	10.1515/znb-2012-0406
Popis:	2-Formyl-1,1,3,3-tetramethylguanidine (1) could be prepared from tris(dimethylamino)ethoxymethane (3a) and formamide (4). Surprisingly, guanidine 1 does not result from the reaction of 1,1,3,3-tetramethylguanidine with formylating reagents such as dimethylamino-methoxy-acetonitrile (8) or the N,N-dimethylformamide-dimethylsulfate adduct (9), rather the isomeric 1,1-dimethyl-3- dimethylaminomethylene-urea (2) is formed. The structure of 2 was confirmed by NMR spectroscopy and crystal structure analysis.
Databáze:	OpenAIRE
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