Facile synthesis of 2-methyl-4-aryl-1H-pyrrole-3-carbonitriles by cathodic reduction of acetonitrile
| Autor: | Taieb Saied, Belen Batanero, Kaouthar Hamrouni, Mohamed Lamine Benkhoud, Fructuoso Barba |
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| Rok vydání: | 2016 |
| Předmět: |
Electrolysis
010405 organic chemistry Galvanic anode Magnesium Aryl Organic Chemistry Inorganic chemistry Phenacyl bromide chemistry.chemical_element 010402 general chemistry 01 natural sciences Biochemistry 0104 chemical sciences law.invention Solvent chemistry.chemical_compound chemistry law Drug Discovery Acetonitrile Pyrrole |
| Zdroj: | Tetrahedron Letters. 57:4673-4675 |
| ISSN: | 0040-4039 |
| DOI: | 10.1016/j.tetlet.2016.09.009 |
| Popis: | A new series of polyfunctionalized pyrroles has been obtained in very good yield when the product of reductive electrolysis of dry acetonitrile (3-aminocrotonitrile anion), is added to different phenacyl bromide solutions at low temperature under an argon atmosphere. The reactive anion is achieved by amperometric reduction of the solvent at stainless steel cathode and using a magnesium sacrificial anode. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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