Intravitreal use of bone marrow mononuclear fraction containing CD34+ stem cells in patients with atrophic age-related macular degeneration
| Autor: | Andre Messias, Luiza Toscano, Rubens Camargo Siqueira, Carina Costa Cotrim, Rodrigo Jorge |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Visual acuity genetic structures medicine.diagnostic_test business.industry CD34 Macular degeneration medicine.disease Fluorescein angiography Peripheral blood mononuclear cell eye diseases 03 medical and health sciences Ophthalmology 0302 clinical medicine Atrophy medicine.anatomical_structure 030221 ophthalmology & optometry medicine sense organs Bone marrow medicine.symptom business Microperimetry 030217 neurology & neurosurgery |
| Zdroj: | Clinical Ophthalmology. 11:931-938 |
| ISSN: | 1177-5483 |
| Popis: | PURPOSE To evaluate the therapeutic potential and safety of intravitreal injections of bone marrow mononuclear fraction (BMMF) containing CD34+ cells in patients with atrophic age-related macular degeneration (AMD). METHODS Ten patients with atrophic AMD and best-corrected visual acuity (BCVA) in the worse-seeing eye of ≤20/100 were enrolled in this study. The bone marrow from all patients was aspirated and processed for mononuclear cell separation. A 0.1 mL suspension of BMMF CD34+ cells was injected into the vitreous cavity of the worse-seeing eye. Patients were evaluated at Baseline and 1,3,6,9 and 12 months after injection. Ophthalmic evaluation included BCVA measurement, microperimetry, infrared imaging, fundus autofluorescence and SD-optical coherence tomography at all study visits. Fluorescein angiography was performed at Baseline and at 6 and 12 months after intravitreal therapy. RESULTS All patients completed the 6-month follow-up, and six completed the 12-month follow-up. Prior to the injection, mean BCVA was 1.18 logMAR (20/320-1), ranging from 20/125 to 20/640-2, and improved significantly at every follow-up visit, including the 12-month one, when BCVA was 1.0 logMAR (20/200) (P |
| Databáze: | OpenAIRE |
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