| Popis: |
Mercuric chloride [25–50 μg/ml platelet-rich plasma (PRP)] lowers the threshold concentration of arachidonic acid (AA) required for triggering rabbit platelet aggregation and causes a marked increase of thromboxane production. The metal, added as HgCl2, does not modify (50.μg/m1 PRP) or block (100 μg/ml PRP) the platelet aggregation wave induced by a normal aggregating dose of AA. Whether or not AA-induced platelet aggregation takes place, a large increase in thromboxane production is observed. Methyl mercury, assayed as reference drug, induces platelet aggregation and a significant increase of thromboxane levels. Finally, HgC12 and methyl mercury, in a concentration range of 0.125–0.5.μg/μl in the incubation liquid, induce an increased prostacyclin release from rat aortic tissue. |
