Abstract P6-08-08: Age-Related differences in clinicopathologic features and survival amongst women with triple negative breast cancer: A population-based study

Autor:	K Martel, J-F Boileau, C Ferrario, Stephanie M. Wong, Mark Basik
Rok vydání:	2018
Předmět:	Oncology Cancer Research medicine.medical_specialty education.field_of_study business.industry Population Cancer medicine.disease Population based study Breast cancer Age related Internal medicine Epidemiology Cohort medicine education business Triple-negative breast cancer
Zdroj:	Cancer Research. 78:P6-08
ISSN:	1538-7445 0008-5472
DOI:	10.1158/1538-7445.sabcs17-p6-08-08
Popis:	INTRODUCTION: Women with triple-negative breast cancers (TNBC) have a tendency to present at younger ages and with more advanced disease. We sought to comprehensively evaluate the characteristic features, surgical management, and survival outcomes of a large, population-based cohort of patients with TNBC according to age at diagnosis. METHODS: We queried the Surveillance, Epidemiology, and End Results (SEER) database to identify women aged 18 years or older with a diagnosis of TNBC between 2010-2014. Clinicopathologic and treatment level variables were compared amongst TNBC patients according to age at the time of TNBC diagnosis. The Kaplan-Meier method and Cox PH Regression was then used to examine short-term breast cancer-specific survival (BCSS) outcomes. RESULTS: Between 2010-2014, 214,138 women were diagnosed with breast cancer, of which 23,614 (11.13%) had TNBC. The median age at TNBC diagnosis was 57.7 years. Younger TNBC patients were more likely to be of African American ( CONCLUSION: In the population studied, more than 40% of very young women with TNBC are of African American or Hispanic race. When compared to older ages, younger women with TNBC are more likely to receive bilateral mastectomy and have more advanced stage at presentation. Women at both age extremes (≥70 years and Citation Format: Wong SM, Boileau J-F, Martel K, Ferrario C, Basik M. Age-Related differences in clinicopathologic features and survival amongst women with triple negative breast cancer: A population-based study [abstract]. In: Proceedings of the 2017 San Antonio Breast Cancer Symposium; 2017 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2018;78(4 Suppl):Abstract nr P6-08-08.
Databáze:	OpenAIRE
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