Effects ofCorylus avellana in acetaminophen and CCl4 induced toxicosis

Autor:	M. Tamas, M. A. Rusu, Bucur N, C. Puică
Rok vydání:	1999
Předmět:	Pharmacology medicine.medical_specialty Glutamate dehydrogenase CCL4 Biology medicine.disease law.invention Acetaminophen Staining chemistry.chemical_compound Endocrinology Biochemistry chemistry law Internal medicine Toxicity medicine Carbon tetrachloride Steatosis Phytotherapy medicine.drug
Zdroj:	Phytotherapy Research. 13:120-123
ISSN:	1099-1573 0951-418X
DOI:	10.1002/(sici)1099-1573(199903)13:2<120::aid-ptr403>3.0.co;2-i
Popis:	Our study investigated the effects of Corylus avellana extract on acetaminophen and carbon tetrachloride intoxicated liver of young rats. Hepatocytolysis was determined by measuring the level of serum transaminases (GPT and GOT), steatosis by Sudan black staining, histological structures by hamatoxylin–eosin staining and the activity of enzymes such as SDH, GtDH, G-6-Pase and ATPase. Comparatively, the most serious lesions appeared in CCl4 intoxication. Corylus avellana extract had some beneficial effects in CCl4 toxicosis: it reduced hepatocytolysis as well as histological lesions and returned the activity of some enzymes to normal values. Copyright © 1999 John Wiley & Sons, Ltd.
Databáze:	OpenAIRE
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