Alkylating Damage by Dipin of Hematopoietic and Stromal Cells of the Bone Marrow

Autor:	Domaratskaia Ei, Paiushina Od, E. I. Bueverova, V. I. Starostin
Rok vydání:	2005
Předmět:	Single administration Stromal cell Spleen Biology General Biochemistry Genetics and Molecular Biology Haematopoiesis medicine.anatomical_structure Stroma Immunology Cancer research medicine Bone marrow Progenitor cell General Agricultural and Biological Sciences
Zdroj:	Biology Bulletin. 32:216-220
ISSN:	1608-3059 1062-3590
Popis:	Effect of alkylating agent dipin was studied on hematopoietic (CFU-S) and stromal (CFU-F) progenitor cells. Single administration of dipin (0.06 mg/g) to adult (CBA × C57Bl/6) F1 hybrid mice induced a long-term (2 years) oscillations in the numbers of day 7 CFU-S and day 11 CFU-S in the bone marrow and spleen. Dipin also damaged the hematopoietic stroma as indicated by decreased numbers of CFU-F which remained low for at least a year. The capacity of stromal cells to form ectopic hematopoietic foci was considerably decreased and also remained low for 10 months. The obtained data suggest high dipin sensitivity of the earliest hematopoietic and stromal cells. The dynamics of CFU-S numbers in the hematopoietic organs supports their functioning on the basis of clonal succession (Kay, 1965).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e50bb6057ba09171e769fdde06ea617e https://doi.org/10.1007/s10525-005-0091-5 Zobrazit plný text záznamu Plný text ve formátu PDF