Constitutional Anemia (Fanconi’s Syndrome) and Leukemia in Two Brothers
| Autor: | R. H. Cowdell, P. J. R. Phizackerley, D. A. Pyke |
|---|---|
| Rok vydání: | 1955 |
| Předmět: |
congenital
hereditary and neonatal diseases and abnormalities Pediatrics medicine.medical_specialty Acute leukemia Hypoplastic anemia Anemia business.industry Immunology Autopsy Cell Biology Hematology medicine.disease Biochemistry Short stature Surgery Leukemia Fanconi anemia hemic and lymphatic diseases Deformity medicine medicine.symptom business |
| Zdroj: | Blood. 10:788-801 |
| ISSN: | 1528-0020 0006-4971 |
| DOI: | 10.1182/blood.v10.8.788.788 |
| Popis: | Two brothers physically very alike became ill in their third decade, one with severe bone marrow hypoplasia and the other with acute leukemia. Both died and the autopsy findings are described. The two shared certain congenital defects, notably short stature with small heads, cutaneous pigmentation, pituitary and genital hypoplasia, and deformity of the thumbs. The brother with hypoplastic anemia also had aortic hypoplasia and his left kidney was absent. No previous report has been discovered of the association of Fanconi’s syndrome (of bone marrow hypoplasia with congenital defects) and leukemia with similar congenital defects in brothers. In two reports of leukemia affecting cousins of patients with Fanconi's syndrome, the leukemic cousins were without congenital defects. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|