Urinary pathogens and drug susceptibility patterns of urinary tract infections among antenatal clinic attendees in Ibadan, Nigeria
| Autor: | Odukogbe Aa, Chris Aimakhu, Kayode S. Adedapo, Aderemi Kehinde, Oladapo Olayemi, Babatunde L. Salako |
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| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
Staphylococcus saprophyticus biology medicine.drug_class Pseudomonas aeruginosa business.industry Antibiotics Obstetrics and Gynecology Klebsiella oxytoca biology.organism_classification medicine.disease_cause Proteus mirabilis Microbiology Nitrofurantoin Internal medicine medicine Ofloxacin business Cefuroxime medicine.drug |
| Zdroj: | Journal of Obstetrics and Gynaecology Research. 38:280-284 |
| ISSN: | 1341-8076 |
| DOI: | 10.1111/j.1447-0756.2011.01635.x |
| Popis: | Aim: To determine the bacterial agents involved in urinary tract infections in pregnant women and their antibiotic susceptibility patterns in Ibadan, Nigeria. Methods: All consenting subjects who attended antenatal clinics of the University College Hospital and Adeoyo Maternity Hospital, Ibadan, Nigeria, from 1 April 2007 and 30 March 2009 were interviewed to obtain demographic and pregnancy health data. Mid-stream urine samples obtained were processed by standard methods. Confirmed bacterial isolates were tested against seven antibiotics using the Kirby–Bauer disc diffusion technique. Results: Of the 473 specimens processed, 136 (28.8%) were positive for microscopy, 118 (25.0%) were culture positive, while 18 (3.8%) were microscopy positive but negative for culture. More than 90% of the bacterial isolates were Gram-negative bacilli, of which approximately 80% were members of the family Enterobacteriaceae. Klebsiella oxytoca accounted for 45 (38.1%) of the causative agents identified, followed by Escherichia coli (31.3%), Pseudomonas aeruginosa (9.3%) and Proteus mirabilis (6.8%). Candida albicans accounted for three (2.6%) of the isolates. Ten isolates (22.2%) of K. oxytoca were resistant to cefuroxime while three (6.7%) were resistant to ofloxacin. The only Gram-positive bacterium isolated, Staphylococcus saprophyticus, accounted for four (4.3%) of all pathogens, of which three (75.0%) were susceptible to nitrofurantoin, ofloxacin, cefuroxime and the amoxicillin–clavulanic acid combination. Conclusions: In conclusion, the incidence of culture-positive urinary tract infection in pregnancy is common in Ibadan. More studies are needed to evaluate the susceptibility profile of uropathogens to commonly used antibiotics in our environment. |
| Databáze: | OpenAIRE |
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