Recent Developments in Treating Alzheimer’s Disease
| Autor: | Robert Layfield, Natasa Kopitar Jerala, Eva Zerovnik |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Microglia biology business.industry Autophagy Inflammation Disease medicine.disease_cause Bioinformatics medicine.disease 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Immunology medicine biology.protein medicine.symptom Antibody Alzheimer's disease business 030217 neurology & neurosurgery Oxidative stress Intracellular |
| Zdroj: | Journal of Alzheimer's Disease & Parkinsonism. |
| ISSN: | 2161-0460 |
| DOI: | 10.4172/2161-0460.1000220 |
| Popis: | Early diagnosis and efficient treatment for sporadic Alzheimer’s disease (AD) are urgently needed as the condition becomes an increasing burden within aging societies. We collected recent data on the progress towards effective treatments of AD, from targeting Aβ aggregation, passive immunization with anti-Aβ antibodies, fighting acute and chronic inflammation, modulating autophagy to balancing metals ions. We argue that from successful model studies and pre-clinical trials, insights into the critical pathogenic mechanisms at the molecular and cellular levels are confirmed. They in one way or another seem to support the modified amyloid cascade hypothesis, in which Aβ oligomers are believed to impair intracellular membranes, possibly resulting in mitochondrial and lysosomal dysfunctions that may lead to oxidative stress and impairment in protein clearance by autophagy, respectively. In accordance, chronic inflammation due to activation of microglia, is also consistently observed in AD brains. |
| Databáze: | OpenAIRE |
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