Insulin-Like Growth Factor I Is Not a Useful Marker of Prostate Cancer in Men with Elevated Levels of Prostate-Specific Antigen1
| Autor: | Markku Seppälä, Sakari Rannikko, Teuvo L.J. Tammela, Anssi Auvinen, Hannu Koistinen, Matti Hakama, Wan-Ming Zhang, Patrik Finne, Liisa Määttänen, Ulf-Håkan Stenman |
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| Rok vydání: | 2000 |
| Předmět: |
medicine.medical_specialty
business.industry Endocrinology Diabetes and Metabolism medicine.medical_treatment Biochemistry (medical) Clinical Biochemistry Odds ratio medicine.disease Biochemistry Confidence interval Prostate cancer Insulin-like growth factor Prostate-specific antigen Endocrinology medicine.anatomical_structure Antigen Prostate Internal medicine Blood plasma Medicine business |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 85:2744-2747 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jcem.85.8.6725 |
| Popis: | High serum levels of insulin-like growth factor I (IGF-I) and low levels of IGF-binding protein-3 (IGFBP-3) have been shown to correlate with increased prostate cancer risk. To evaluate this, IGF-I, IGFBP-3, and prostate-specific antigen (PSA) were measured in serum from 665 consecutive men (179 with prostate cancer), aged 55–67 yr, with elevated serum prostate-specific antigen (PSA; ≥4 μg/L) in a screening trial. Men in the highest quartile of IGF-I levels had an odds ratio (OR) for prostate cancer of 0.50 [95% confidence interval (CI) 0.26–0.97] when adjusting for serum IGFBP-3. IGFBP-3 itself was not significantly associated with prostate cancer risk (OR, 1.24; 95% CI, 0.68–2.24). Prostate volume was larger in men without than in those with prostate cancer (P < 0.001), and after adjustment for prostate volume, the negative association between serum IGF-I and prostate cancer risk was no longer significant (OR, 0.57; 95% CI, 0.28–1.16). In screen-positive men with elevated serum PSA, serum IGF-I is not a useful diagnostic test for prostate cancer, but it may be associated with benign prostatic hyperplasia and enlargement. |
| Databáze: | OpenAIRE |
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