Novel methodology for labelling mesoporous silica nanoparticles using the 18F isotope and their in vivo biodistribution by positron emission tomography
| Autor: | Milagros Rocha, Herme G. Baldoví, Sergio Abad, Mireia Buaki-Sogo, Santiago Rojas, Hermenegildo García, Victor M. Victor, Juan Domingo Gispert, Cristina Menchón, José Raúl Herance |
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| Rok vydání: | 2015 |
| Předmět: |
Biodistribution
Materials science medicine.diagnostic_test Radiochemistry Nanoparticle Bioengineering Nanotechnology General Chemistry Mesoporous silica Condensed Matter Physics Atomic and Molecular Physics and Optics Pharmacokinetics Positron emission tomography Modeling and Simulation Labelling medicine General Materials Science Positron emission Drug carrier |
| Zdroj: | Journal of Nanoparticle Research. 17 |
| ISSN: | 1572-896X 1388-0764 |
| DOI: | 10.1007/s11051-015-2938-0 |
| Popis: | Nanoparticles have been proposed for several biomedical applications due to their potential as drug carriers, diagnostic and therapeutic agents. However, only a few of them have been approved for their use in humans. In order to gauge the potential applicability of a specific type of nanoparticle, in vivo biodistribution studies to characterize their pharmacokinetic properties are essential. In this regard, mesoporous silica nanoparticles (30–130 nm) have been functionalized with amino groups in order to react with N-succinimidyl 4-[18F]fluorobenzoate and thus anchor the 18F positron emission isotope by using a novel and easy labelling strategy. In vivo biodistribution was characterized in mice after intravenous administration of radiolabelled nanoparticles by positron emission tomography. Our results indicated that radiolabelled mesoporous silica nanoparticles were excreted into bile and urine and accumulated mainly in the organs of the reticuloendothelial system and lungs. |
| Databáze: | OpenAIRE |
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