Palladium-Catalyzed α-Arylation Reactions in Total Synthesis

Autor:	Thomas J. Colacot, Ibrahim Ibnusaud, Sudheesh T. Sivanandan, Carin C. C. Johansson Seechurn, Ashna Shaji
Rok vydání:	2014
Předmět:	chemistry.chemical_compound Chemistry Organic Chemistry Total synthesis Organic chemistry chemistry.chemical_element Homogeneous catalysis Organic synthesis Physical and Theoretical Chemistry Combinatorial chemistry Palladium Catalysis
Zdroj:	European Journal of Organic Chemistry. 2015:38-49
ISSN:	1434-193X
DOI:	10.1002/ejoc.201403301
Popis:	The development of palladium-catalyzed α-arylation of carbonyl compounds has emerged as a new avenue in the design of new routes for the synthesis of natural products and active pharmaceutical ingredients (APIs). In many cases, syntheses based on α-arylation strategies provide elegant routes in terms of increasing the overall yields, improving the synthesis scope, and decreasing the number of steps. This microreview aims to highlight the importance of palladium-catalyzed α-arylation methodologies, covering a range of notable reported examples of the total syntheses of structurally important compounds, thereby highlighting the importance of this powerful methodology for key steps in organic synthesis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e4dd62eb7641eed87979cfa9d8a0d8f8 https://doi.org/10.1002/ejoc.201403301 Zobrazit plný text záznamu Plný text