| Autor: |
Ogochukwu Rita Ngwu, Uchechukwu Chibuzo Ogbodo, Chidiebere Malachy Chigbo, Obiajulu Christian Ezeigwe, Chioma Divine Anwuna, Chukwuemeka Obumneme Okpala |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Asian Journal of Research in Biochemistry. :1-6 |
| ISSN: |
2582-0516 |
| DOI: |
10.9734/ajrb/2020/v6i230111 |
| Popis: |
Background: Anemia is a condition in which there is a reduced number of red blood cells or haemoglobin and iron concentration in the body thereby leading to a decreased capacity of the blood to carry oxygen to the body tissues. Objectives: The study was designed to investigate the effect of a combination of ethanol extract of Ficus capensis and Cnidoscolus aconitifolius in phenylhydrazine-induced anemic rats. Methods: The animals were divided into five groups of five rats each. Group A served as normal control, Group B as anemic control, group C as standard drug control, groups D and E were treated with 200 mg/kg and 400 mg/kg of combined ethanol leaf extract of F. capensis and C. aconitifolius respectively. Phenylhydrazine was administered intraperitoneally at a dose of 20 mg/kg b.w. for two days to induce anemia in rats. The administration of the extract lasted for 14 days after which the animals were sacrificed and blood obtained through cardiac puncture for kidney and liver biomarkers analyses. Results: Aspartate aminotransferase, Alanine aminotransferase, Alkaline phosphatase, Total bilirubin, Direct bilirubin and Kidney function parameters assayed in the anemic untreated group showed significant increases (p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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