Improving the treatment of the novel coronavirus infection (COVID-19) in children at risk for the development of severe disease with the use of virus-neutralizing monoclonal antibodies
| Autor: | A. S. Tokarev, I. M. Osmanov, L. N. Mazankova, I. N. Zakharova, E. R. Samitova, S. O. Kotenko |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 67:23-33 |
| ISSN: | 2500-2228 1027-4065 |
| DOI: | 10.21508/1027-4065-2022-67-3-23-33 |
| Popis: | This study presents the results of treatment of 98 patients with risk of development of severe coronavirus disease (hereinafter COVID-19) with the first positive result of polymerase chain reaction test for SARS-CoV-2 in a day clinic of the multidisciplinary Z.A. Bashlyaeva Children’s Municipal Clinical Hospital. To prevent the clinical manifestation of COVID-19 and the progression of the main disease all these children were treated with virus-neutralizing monoclonal antibodies (sotrovimab 500 mg dissolved in 92 mL of 0.9% sodium chloride solution intravenously for 30 minutes, once, for children over 12 years old and with body weight over 12 kg; balanivimab 700 mg + etesivimab 1400 mg pre-dissolved in 250 mL of 0.9% sodium chloride solution intravenously for 30 minutes, once). Patients underwent a comprehensive clinical, laboratory and instrumental examination both initially and in dynamics for 3–7–11 days after therapy according to the developed clinical algorithm. The effectiveness of biological therapy in children with a risk of severe COVID-19 was noted in 100% of cases. None of the observed patients had either a clinical manifestation of COVID-19 or a relapse of the main chronic disease. |
| Databáze: | OpenAIRE |
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