Synthesis of N,N′,2-triaryl-6-hydroxy-6-methyl-4-oxocyclohexane-1,3-dicarboxamides and their reactions with p-toluidine and hydrazine hydrate

Autor:	T. F. Odegova, A. N. Yankin, V. L. Gein, N. V. Nosova
Rok vydání:	2015
Předmět:	Ethanol Hydrazine General Chemistry medicine.disease Antimicrobial Cyanoacetic acid hydrazide chemistry.chemical_compound P-toluidine chemistry medicine Organic chemistry Piperidine Dehydration Hydrate
Zdroj:	Russian Journal of General Chemistry. 85:46-52
ISSN:	1608-3350 1070-3632
DOI:	10.1134/s1070363215010089
Popis:	Reaction of N-arylacetoacetamides with aromatic aldehydes in the presence of piperidine in ethanol afforded N,N′,2-triaryl-6-hydroxy-6-methyl-4-oxocyclohexane-1,3-dicarboxamides. The latter reacted with p-toluidine leading to the formation of dehydration products. Reactions of N,N′,2-triaryl-6-hydroxy-6-methyl-4-oxocyclohexane-1,3-dicarboxamides with hydrazine hydrate and cyanoacetic acid hydrazide gave rise to tetrahydroindazoles. Some of the obtained compounds showed antimicrobial activity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e4d2b573399241d2f193f3ceb759f3f4 https://doi.org/10.1134/s1070363215010089 Zobrazit plný text záznamu Plný text ve formátu PDF