Intratumoral CD3 and CD8 T-cell Densities Associated with Relapse-Free Survival in HCC
| Autor: | Eddie Island, Zoran Gatalica, Andrew T. Gabrielson, Thomas M. Fishbein, Michael B. Atkins, Hongkun Wang, Lynt B. Johnson, Jaydeep Kachhela, Sandeep K. Reddy, Tiger Zhang, Yunan Wu, Perry Feng, Petra Prins, Anteneh Tesfaye, David E. Kleiner, Bhaskar Kallakury, Christopher A. Loffredo, Jiji Jiang, Filip Banovac, Reena Jha, John L. Marshall, Aiwu Ruth He, Louis M. Weiner, Rohits Satoskar |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Cancer Research Pathology medicine.medical_specialty Immunology Cancer Biology medicine.disease Primary tumor Gastroenterology 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Immune system 030220 oncology & carcinogenesis Internal medicine Hepatocellular carcinoma medicine Carcinoma Cytotoxic T cell B7-H1 Antigen CD8 |
| Zdroj: | Cancer Immunology Research. 4:419-430 |
| ISSN: | 2326-6074 2326-6066 |
| Popis: | Immune cells that infiltrate a tumor may be a prognostic factor for patients who have had surgically resected hepatocellular carcinoma (HCC). The density of intratumoral total (CD3+) and cytotoxic (CD8+) T lymphocytes was measured in the tumor interior and in the invasive margin of 65 stage I to IV HCC tissue specimens from a single cohort. Immune cell density in the interior and margin was converted to a binary score (0, low; 1, high), which was correlated with tumor recurrence and relapse-free survival (RFS). In addition, the expression of programmed death 1 (PD-1) and programmed death ligand 1 (PD-L1) was correlated with the density of CD3+ and CD8+ cells and clinical outcome. High densities of both CD3+ and CD8+ T cells in both the interior and margin, along with corresponding Immunoscores, were significantly associated with a low rate of recurrence (P = 0.007) and a prolonged RFS (P = 0.002). In multivariate logistic regression models adjusted for vascular invasion and cellular differentiation, both CD3+ and CD8+ cell densities predicted recurrence, with odds ratios of 5.8 [95% confidence interval (CI), 1.6–21.8] for CD3+ and 3.9 (95% CI, 1.1–14.1) for CD8+. Positive PD-L1 staining was correlated with high CD3 and CD8 density (P = 0.024 and 0.005, respectively) and predicted a lower rate of recurrence (P = 0.034), as well as prolonged RFS (P = 0.029). Immunoscore and PD-L1 expression, therefore, are useful prognostic markers in patients with HCC who have undergone primary tumor resection. Cancer Immunol Res; 4(5); 419–30. ©2016 AACR. |
| Databáze: | OpenAIRE |
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