Anti-Nociceptive and Anti-Inflammatory Activity of Hygrophila schulli Leaves
| Autor: | Mebrahtom Gebrelibanos Hiben, Abrha Desta, Ephrem Mebrahtu Araya, Gebretsadkan Hintsa Tekulu |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Traditional medicine business.industry medicine.drug_class Immunology Analgesic Acute toxicity Anti-inflammatory Carrageenan 03 medical and health sciences Hygrophila schulli chemistry.chemical_compound 030104 developmental biology 0302 clinical medicine chemistry In vivo Hyaluronidase 030220 oncology & carcinogenesis medicine Immunology and Allergy Anti nociceptive business medicine.drug |
| Zdroj: | Journal of Inflammation Research. 13:497-505 |
| ISSN: | 1178-7031 |
| DOI: | 10.2147/jir.s269717 |
| Popis: | Purpose The management of pain and inflammation with non-steroidal anti-inflammatory drugs and opioid analgesics are currently encountering severe adverse reactions. To overcome these problems, herbal remedies may offer new alternative medicines. Hygrophila schulli is a medicinal plant traditionally used for the treatment of pain and inflammation-related disorders; yet, these claims are not scientifically validated. Hence, this study was aimed to validate the traditional use of Hygrophila schulli leaves as anti-inflammatory and analgesic remedy. Methods In vitro anti-hyaluronidase assay and in vivo carrageenan-induced hind paw oedema model were used to evaluate the anti-inflammatory property of ethanolic leaf extract of Hygrophila schulli. Tail immersion and acetic acid-induced writhing tests were performed to determine the central and peripheral analgesic activity of the leaf extract, respectively. Results The ethanolic leaf extract exhibited significant anti-hyaluronidase activity (P |
| Databáze: | OpenAIRE |
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