Tumour necrosis factor receptor superfamily member 11B polymorphisms and association with knee osteoarthritis in women

Autor:	M. J. Perry, Sarah Hulin-Curtis, J. L. Bidwell
Rok vydání:	2012
Předmět:	musculoskeletal diseases Oncology medicine.medical_specialty Immunology Intron Single-nucleotide polymorphism General Medicine Osteoarthritis Biology medicine.disease Osteoprotegerin Internal medicine Genotype Genetics medicine Allele Receptor Molecular Biology Allele frequency Genetics (clinical)
Zdroj:	International Journal of Immunogenetics. 39:207-209
ISSN:	1744-3121
DOI:	10.1111/j.1744-313x.2012.01083.x
Popis:	We examined single-nucleotide polymorphisms (SNPs) across the tumour necrosis factor receptor superfamily member 11B (TNFRSF11B) gene and knee OA. We identified alleles in a VNTR region in intron 3 that was observed exclusively in women OA cases (P = 0.007, Pc = 0.042). Our results reveal that a previously unreported association between a VNTR genotype in TNFRSF11B and knee OA in women.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e4ae290e985344d3f7e96a9135ed2369 https://doi.org/10.1111/j.1744-313x.2012.01083.x Zobrazit plný text záznamu Plný text ve formátu PDF