Nonalcoholic fatty liver disease: an independent risk factor for colorectal neoplasia
| Autor: | A. Heuberger, Florian Hohla, Elmar Aigner, Wolfgang Patsch, Eric J. Brunner, Astrid Mayr, Christian Datz, Dieter Lederer, Andreas Stadlmayr, Michael Strasser, L. Scharinger, J. Steinwendner, B. Steger |
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| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
medicine.diagnostic_test Adenoma business.industry Colorectal cancer Fatty liver Colonoscopy medicine.disease Gastroenterology digestive system diseases Tubular adenoma Dysplasia Internal medicine Nonalcoholic fatty liver disease Internal Medicine medicine Risk factor business |
| Zdroj: | Journal of Internal Medicine. 270:41-49 |
| ISSN: | 0954-6820 |
| DOI: | 10.1111/j.1365-2796.2011.02377.x |
| Popis: | Stadlmayr A, Aigner E, Steger B, Scharinger L, Lederer D, Mayr A, Strasser M, Brunner E, Heuberger A, Hohla F, Steinwendner J, Patsch W, Datz C (Oberndorf Hospital, Oberndorf; Paracelsus Medical University, Salzburg, Austria). Nonalcoholic fatty liver disease: an independent risk factor for colorectal neoplasia. J Intern Med 2011; 270: 41–49. Abstract. Background and aims. Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of insulin resistance (IR), and IR is associated with an increased risk of colorectal carcinoma (CRC). Increased echogenicity suggesting NAFLD is a frequent incidental finding on ultrasound examination. We aimed to systematically evaluate whether NAFLD is an independent risk factor for colonic neoplasia. Patients and methods. One thousand two hundred and eleven patients (603 males, 60.6 ± 9.6 years; 608 females, 61.1 ± 10.3 years) who underwent screening colonoscopy according to national screening recommendations for CRC were evaluated in a cross-sectional study. Colorectal adenomas were classified as tubular adenoma, advanced adenoma (villous features, size ≥1 cm or high-grade dysplasia) or carcinoma. NAFLD was diagnosed by increased echogenicity on ultrasound examination after serological exclusion of infectious, immunological, hereditary or alcoholic aetiology. Results. Nonalcoholic fatty liver disease was diagnosed in 367 (60.8%) males and in 265 (43.5%) females. The total rate of adenomas was increased in subjects with NAFLD (243/367 vs. 107/236 in males, P = 0.010; 94/265 vs. 78/343 in females; P = 0.014). In particular, more tubular adenomas (127/367 vs. 56/236; P = 0.006), adenomas of the rectum (40/367 vs. 8/236; P = 0.004) and more cancers (6/367 vs. 1/236; P |
| Databáze: | OpenAIRE |
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