The no-reflow phenomenon: mechanisms and therapeutic targets
| Autor: | Michael M. Galagudza, D. L. Sonin, E. I. Pochkaeva |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Cardioprotection
medicine.medical_specialty business.industry medicine.medical_treatment General Engineering Percutaneous coronary intervention 030204 cardiovascular system & hematology medicine.disease 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Internal medicine No reflow phenomenon cardiovascular system medicine Cardiology cardiovascular diseases Myocardial infarction Embolization Thrombus business Perfusion Artery |
| Zdroj: | Regional blood circulation and microcirculation. 17:5-12 |
| ISSN: | 1682-6655 |
| Popis: | The phenomenon of «no-reflow» refers to a state of myocardial tissue hypoperfusion or absence of perfusion after eliminating the cause of the occlusion of the coronary artery. Two main pathogenetic mechanisms may contribute to the development of no-reflow phenomenon after primary percutaneous coronary intervention in patients with myocardial infarction: ischemic-reperfusion injury of the microcirculatory vessels and embolization of the distal arterial bed with fragments of thrombus and atherosclerotic plaque. In this review, we describe the pathophysiological mechanisms of no-reflow, risk factors for no-reflow phenomenon, the principles of diagnosis and therapeutic targets. |
| Databáze: | OpenAIRE |
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