An efficient route to chiral, non-racemic 3-alkyl-3-arylpyrrolidines. Improved stereoselectivity in alkylation of bicyclic lactams and the effect of leaving groups
| Autor: | Kozo Oda, Albert I. Meyers |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
chemistry.chemical_classification
Bicyclic molecule Organic Chemistry biochemical phenomena metabolism and nutrition Alkylation Biochemistry Medicinal chemistry chemistry Drug Discovery Electrophile polycyclic compounds lipids (amino acids peptides and proteins) Stereoselectivity Trifluoromethanesulfonate Alkyl |
| Zdroj: | Tetrahedron Letters. 41:8193-8197 |
| ISSN: | 0040-4039 |
| DOI: | 10.1016/s0040-4039(00)01471-4 |
| Popis: | Chiral 3-alkyl-3-arylpyrrolidines were prepared from the substituted bicyclic lactams. Stereoselectivity in the alkylation of bicyclic lactams was improved by using an alkyl triflate or tosylate as the electrophile. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect