Synthesis and anticoagulant activity of 1-aryl derivatives of tetrahydroisoquinolines

Autor:	B. Ya. Syropyatov, N. G. Ismailova, K. A. Arapov, O. N. Minova, Vladimir A. Glushkov, Yu. V. Shklyaev
Rok vydání:	2006
Předmět:	Pharmacology chemistry.chemical_compound Chemistry Aryl Drug Discovery Condensation Pharmacology toxicology Organic chemistry Isobutylene oxide Anticoagulant activity
Zdroj:	Pharmaceutical Chemistry Journal. 40:363-366
ISSN:	1573-9031 0091-150X
DOI:	10.1007/s11094-006-0128-1
Popis:	A series of 1-aryl-3,3-dimethyl-3,4-dihydroisoquinolines were obtained by three-component (one-pot) condensation of veratrole, isobutylene oxide, and aromatic nitriles and then reduced to the corresponding 1,2,3,4-tetrahydroisoquinolines. Hydrochlorides of the synthesized compounds were tested for anticoagulant activity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e49f6ee81748f9261c262894c4e84114 https://doi.org/10.1007/s11094-006-0128-1 Zobrazit plný text záznamu Plný text ve formátu PDF