An Alternative Method for Determination of Additives in Polypropylene Using Supercritical Fluid Extraction and Enhanced Solvent Extraction

Autor:	Jan Östelius, Ulla Gasslander, Bengt Erlandsson, Anne De Paepe, Astrid Arbin
Rok vydání:	2006
Předmět:	Polypropylene Chromatography Clinical Biochemistry Extraction (chemistry) Supercritical fluid extraction Pharmaceutical Science Biochemistry High-performance liquid chromatography Analytical Chemistry Solvent chemistry.chemical_compound chemistry Sample preparation Methanol Dissolution
Zdroj:	Journal of Liquid Chromatography & Related Technologies. 29:1541-1559
ISSN:	1520-572X 1082-6076
Popis:	The extraction of Irganox 1076, Irgafos 168, and Irganox 1010 from polypropylene (PP) by supercritical fluid extraction (SFE) and enhanced fluid extraction (ESE) was investigated to find an alternative method to the dissolution extraction required by regulators for polymers used for the packaging of liquid pharmaceutical formulations. The maximum recovery with SFE was obtained at a CO2 pressure of 680 bar at a temperature of 100°C, with 10% methanol as modifier and static and dynamic extraction times of 30 and 40 minutes, respectively. This gave a recovery of ≥95% for Irganox 1076 and Irgafos 168 compared to the pharmacopoeial method, and a recovery of 62% for Irganox 1010. With ESE, the maximum extraction was obtained at a temperature of 100°C, a restrictor flow rate of 5 mL/min, a static extraction time of 90 minutes, and a solvent mixture of 2‐propanol-cyclohexane (75:25 v/v). The recoveries for Irganox 1076 and Irgafos 168 were 109% and 121%, respectively, compared to the pharmacopoeial metho...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e48c52f07e0d46b3c3bbca2710e71cf0 https://doi.org/10.1080/10826070600675387 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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